Handmade Potion

On 27 December, Shibuya HAL joined Handmade Potion's Apex Legends professional team.

On 6 May, Handmade Potion announced the upcoming debut of three new VTubers: Satou Amasa, Hibiki Kanon, and Mizuki Aoi. On 16 May, Satou Amasa, Hibiki Kanon, and Mizuki Aoi debuted in a relay on YouTube. On 21 August, the independent VTuber Usami joined Handmade Potion.

On 21 March, Yamanashi Minato and Tsunaki Sakurako (a.k.a "Nova Ciena Arkhipova" / ノヴァ・シエナ・アルヒポワ) made their debuts, with Minato becoming Handmade Potion's first in-house male VTuber. On 22 July, Handmade Potion announced that Hiiragi Konoha and Saeki Asuka have joined the organization. On 16 December, ex-Apex Legends pro team member Sapoten debuted his Live2D model and became a VTuber. He is listed under the VTuber section of the website.

On 14 January, Handmade Potion announced that Yamanashi Minato will be graduating due to personal circumstances, effective on 31 March 2022. On 30 November, Saeki Asuka announced that she will be graduating on 31 December 2022 and going into indefinite hiatus afterward, due to her personal life becoming too busy and changes in her environment that make it difficult to continue streaming. On 15 December, Handmade Potion officially confirmed that Saeki Asuka will be graduating, effective on 31 December 2022.

On 5 April, Sapoten rejoined the organization.