On 25 January, she reached 300,000 YouTube subscribers.
On 20 February, hololive's Twitter account announced that AZKi would get her third 3D model.
On 23 February, AZKi debuted her third 3D model during a concert on her YouTube channel.
During her 7th live concert "Stand at the crossroads" on 11 April, AZKi revealed that AZKi Project was meant to end on July 2022. However, there are still many dreams she'd like to pursue that she wants to move beyond that end goal, going "from Route Alpha to Route Beta." Exactly what this entails is yet to be explicated. She also reached 400,000 susbcribers in her YouTube channel during this concert.
As a part of her birthday celebration, AZKi held a concert with Tsunomaki Watame and Momosuzu Nene on 3 July where she also debuted an updated version of her second costume, more in line with her third costume's visual style.
On 14 August, she reached 500,000 YouTube subscribers, making her the 41st hololive member to reach this milestone. She is also the last one of the Gen 0 to achieve it.
On 12 September, she held her eighth concert named "Rewind & Reunion" on Z-aN. The event was originally scheduled for 13 March at Ikebukuro harevutai, but had to be postponed due to the COVID-19 pandemic.
On 29 December, hololive's Twitter account announced that AZKi would be transfered to the main hololive branch in April 2022. A few hours later, AZKi made a post on her Twitter account explaining her transfer and thanking everyone for the three years so far, confirming the dissolution of INoNaKa MUSIC. Various hololive members welcomed her into the main branch, hoping to work together with her in the future. On the same day, her manager Tsuranimizu announced their retirement for the same reason.