On 1 January, Lui debuted her second 2D costume, a furisode to celebrate the new year. In this costume, Lui got a new hairstyle, a side curly ponytail to the right. Above her ponytail, Lui can wear a small black hat decorated with feathers in the same color. The hat also has a golden hawk decoration to the right and some flowers. She wears a single earring on her left ear. Her furisode is striped blue and black. The blouse is blue to the right and black to the left, with the left side folded over the right side and the black side dominant on her top. The skirt is also folded in the same direction. However as the colors are inverted, blue is the dominant color in her skirt. The edges of the furisode are wavy, black for the sleeves, white for the middle open section, and black and white at the end of the it. The inner part of the furisode has a pattern of feathers. The furisode has a brown corset decorated with a long red ribbon. Her shoes are white and brown. Lui can also wear a white, fluffy piece of cloth.
On 11 January, Lui reached 400,000 subscribers on her YouTube channel during a stream of "Pokémon Shining Pearl."
On 1 April, Lui uploaded a teaser video introducing the Dating Simulation Game named "Horo ni koisuru" (「ホロに恋する」, lit. Fall in love with Holo) that she produced herself. The video has the appearance of: Sakura Miko, Aki Rosenthal, Oozora Subaru, Nekomata Okayu, Houshou Marine, Tsunomaki Watame, Yukihana Lamy, Hakui Koyori, Kureiji Ollie, and Ouro Kronii.
On 26 April, Lui reached 500,000 YouTube subscribers during an endurance karaoke stream. This makes her the 52nd hololive member to reach this milestone, and the last of her generation to do so.
On 11 June, during her birthday stream, Lui announced her first original song.
On 14 June, Lui announced that she would get her 3D model.
On 21 June, she debuted her 3D model.
On 28 July, she released the full music video of her original song "Overd."
On 10 August, as part of the "hololive Summer 2022" event, Lui debuted her 3D swimsuit. Unlike the original swimsuits from 2019 that had individual designs, these swimsuits are meant to be matching outfits similar to the 3D idol costumes. The swimsuits come in two types one with thin straps for the top and a diagonal cut mini skirt and the other one has ruffled straps in the top and an even mini skirt. Both version are white with various patterns including hololive's and Holoearth's logos, hearts and sparks. The swimsuits are personalized by including different colors to match each talent. Additionally they have the option to wear a hoodie.
On 22 August, continuing the "hololive Summer 2022" event, Lui debuted her 3D yukata. Like other 3D costumes the yukatas have a variety of styles that hololive members can choose from. The yukatas come in various colors and patterns including fireworks, flowers and goldfish.
On 1 September, Lui reached 600,000 subscribers on her YouTube channel.
On 19 October, Lui debuted a new hairstyle for her new year costume using long loose hair.
On 16 November, during a stream on Koyori's channel, holoX announced that they would get their 3D idol costumes.
On 27 November, Lui celebrated her first year anniversary. During the stream, she debuted her 3D idol costume and released the second original song "TSUBASA."
On 4 December, during holoX first year anniversary, they released their first original song "Jouya Repaint."
On 21 December, during a holoX meeting stream, Lui, Hakui Koyori, Sakamata Chloe and Kazama Iroha debuted their 3D christmas costumes.