On 17 January, Vox reached 200,000 subscribers on his YouTube channel
On 26 January, Vox appeared on Ironmouse's talk show, "Speak of the Devil".
On 10 February, Vox reached 300,000 subscribers on his YouTube channel.
On 27 February, Luxiem's debut celebration voice packs went up for sale.
On 6 March, Vox reached 400,000 subscribers on his YouTube channel.
On 15 March, Vox's White Day 2022 voice pack and goods went up for sale.
On 18 March, Vox reached 400,000 followers on his Twitter account.
On 28 March, Vox reached 500,000 subscribers on his YouTube channel.
On 1 April, Vox reached 522,000 subscribers on his YouTube channel during a 5 h 22 min stream. This milestone is significant as one of Vox's goals for 2022 and since it pertains to the number 522, the size of Vox's original clan in Sengoku.
On 14 April, Vox reached 500,000 followers on his Twitter account. On the same day, he held his first (unarchived) karaoke stream in celebration of 522,000 subscribers. The stream peaked at around 59,000 concurrent viewers.
On 20 April, Vox reached 600,000 subscribers on his YouTube channel.
On 22 April, Vox's Sakura Bloom 2022 voice pack and goods went up for sale.
On 25 April, Vox's birthday goods and voice went up for sale.
On 1 May, each Luxiem member received an official bilibili account. Vox also reached 100 captains on bilibili the same day. A captain on bilibili is the equivalent of a YouTube channel membership.
On 6 May, Vox had his first bilibili-exclusive stream to celebrate the 1-year anniversary of NIJISANJI EN. During the stream, he reached 425,000 cumulative viewers, first in popularity for the VTuber and overall categories, over 700,000 followers on bilibili, and over 14 million cumulative streamer points. He also reached 1000 captains on bilibili the same day.
On 9 May, Vox held his first sponsored stream for the game "" by which focused on the game's new updates and features.
On 11 May, Vox reached 700,000 subscribers on his YouTube channel.
On 27 May, Vox reached 1,000,000 followers on his bilibili channel.
On 4 June, Vox reached 800,000 subscribers on his YouTube channel.
On 9 June, Luxiem's YouTube channel was created.
On 21 June, Vox reached 800,000 followers on his Twitter account.
On 1 July, Vox reached 900,000 subscribers on his YouTube channel.
On 13 July, Vox reached 900,000 followers on his Twitter account.
On 19 July, Vox appeared on Projekt Melody's podcast, "Lewdcast".
On 24 July, Vox reached 1,000,000 subscribers on his YouTube channel. He reached this milestone in 216 days, over 7 months after debut, making him the first NIJISANJI EN member and the 4th NIJISANJI Liver overall to reach this milestone.
On 30 July, Vox reached 1,000,000 followers on his Twitter account.
From 21 November until 22 November, Vox began a series of cryptic tweets that elude to his lore. In these tweets, Vox used the first letter of each tweet to spell "four hundred years," ending the series of tweets with an announcement of his first cover of New Cydonia by Starcadian released on November 25, which is a mix of the original and alternative version of the song featuring backing vocals of fellow NIJISANJI EN Liver Enna Alouette.